The cybersecurity threat landscape is constantly actively making it imperative to develop sound frameworks to protect the IT structures. Based on this introduction, this paper aims to discuss the application of cybersecurity frameworks into the IT security with focus placed on the role of such frameworks in addressing the changing nature of cybersecurity threats. It explores widely used models, including the NIST Cybersecurity Framework, Zero Trust Architecture, and the ISO/IEC 27001, and how they apply to industries including finance, healthcare and government. The discussion also singles out such technologies as Artificial Intelligence (AI) and Machine Learning (ML) as the core for real-time threat detection and response mechanisms. As these integration challenges demonstrate, the study provides tangible and proven approaches to tackle framework implementation issues such as legitimate security issues, limited availability of funds and resources, and compliance with legal requirements. By capturing current trends and exposures, the findings promote strong, portfolio-based and risk-appropriate security approaches adjusted for organizational goals and capable to prevent advanced cyber threats.