To Lyse or Not: The Role of Half-Dose Thrombolysis in Right Ventricular Clot Associated with Sub-Massive Pulmonary EmbolismNasreldin A. Hamza1, Wasfy J. Hamad1, Shamim K. Vakkulathil1, Vimalraj Sundaram1, Haidar M. Hadi2, Abdulqadir J. Nashwan3*1 Critical Care Department, Al-Khor General Hospital, Hamad Medical Corporation, Doha 3050, Qatar2 Cardiology Department, Al-Khor General Hospital, Hamad Medical Corporation, Doha 3050, Qatar3 Nursing Department, Hamad Medical Corporation, Doha 3050, Qatar*Corresponding author:Mr. Abdulqadir J. [email protected]: (+974) 66473549, P.O. Box 3050 Doha, QatarORCID: https://orcid.org/0000-0003-4845-4119E-mails: [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]

A document by Dharaneswari Hari Narayanan. Click on the document to view its contents.

As Internet middleboxes become increasingly prevalent, their influence on traffic streams presents significant challenges and opportunities for network management. Among these devices, transparent middleboxes are particularly difficult to detect, as they can modify traffic patterns without altering content, thereby preserving the appearance of normal routing. This paper addresses the challenge of detecting such transparent middleboxes by proposing a generalized detection framework capable of identifying a broad range of middlebox behaviors, including those that operate transparently. In contrast to existing ad hoc approaches that target specific middlebox types, our framework is novel in its ability to detect a wide variety of middleboxes instead. We validate the effectiveness of our approach through a combination of analytical methods, network simulations, and live Internet experiments. Our results demonstrate the framework's capability to accurately detect widely employed middlebox behaviors, such as network compression, traffic prioritization, and traffic shaping.

Neonatal hyperammonemia is usually due to a reduction in the metabolic capacity of the urea cycle. However, critically ill infants often present with several risk factors leading to high blood ammonia levels, including increased production and/or decreased elimination of ammonia. We present a rare case of an 11-day-old female infant with

Huge hepatic cysts cause congestive heart failure

Case Report：Oesophageal Perforation Caused by Late Screw Displacement After Anterior Cervical PlatingHaoran Chen 1, Qianliang Wang 1,Fengxian Jiang 1*1. 1Department of Orthopedics, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, P. R. China2.*Corresponding author:Fengxian Jiang, Department of Orthopedics, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, P. R. ChinaE-mail: [email protected]

Eagle’s syndrome a rare cause of neck pain: a case report

Hypereosinophilia Associated With Antisynthetase Syndrome With anti-Ro52/PL12 Co-Positivity: An Unusual PresentationKapuczinski A.1, Demeulenaere N.1, Rossi C.2, Bondue B.3, Léon M.11Rheumatology Department, CHU HELORA site Kennedy, Mons, Belgium; 2Infectious Disease Department, CHU HELORA site Kennedy, Mons, Belgium, 3Pneumology Department, Hôpital Erasme, Bruxelles, Belgium.Correspondence : Abeline Kapuczinski; [email protected]

To study on the proteome and to investigate the immune response mechanisms in P. skrjabini infection. Serum samples were randomly collected from patients with P. skrjabini infection and healthy individuals in Guizhou Province. ITRAQ (Isobaric Tags for Relative and Absolute Quantitation) assays were utilized for the analysis of protein catalogs in serum samples. Bioinformatics analysis on the differed proteins was performed. River crabs were sampled from the patients’ habitats, Paragonimus metacercariae were isolated for subsequent rat experimental infection. White blood cells and serum were collected at 42 days post-infection, changes in the expression of IL-4 were assessed. In result, a total of 50 proteins were identified. Typically, increased expression neutrophil defensin 3, protein S100-A9 (S100A9) and serum amyloid A-1 protein (SAA1) were found. S100A9 and SAA1 were involved in the main network but DEFA3 was not. The interaction networks were constituted with the core of Apolipoproteins family and the interactions with the fibrinogen and fibrinolytic system. Through subsequent experimental infections in rats, the expression of Th2 cytokines IL-4 remains unaltered. In conclusion, neutrophils may play a pivotal role in the elimination of parasites, whereas host Th2 cell immune response is suppressed in eliminating worms.

Magnetothermal neuromodulation is a minimally-invasive, deep-brain accessible and tether-free technique. The precisely timed activation of thermosensitive ion channels, such as TRPV1, with local heat generated using magnetic nanoparticles is crucial for efficient neuromodulation. Nevertheless, this technique is greatly hindered by its long stimulus-response time and high safety risks due to the poor heat-generating performance of the nanomediators. Herein, we report the establishment of a ferrimagnetic vortex iron oxide nanoring (FVIO)-mediated magnetothermal neurostimulation technique that is efficient and safe. Compared with widely used superparamagnetic iron oxide nanomediators (SPIOs), the FVIOs triggered Ca2+ influx into HEK293T cells and cortical neurons at an Fe concentration of 54 μg/mL, which is 20.27-fold lower than that needed for SPIOs. In vivo magnetothermal stimulation in the central nucleus of the amygdala of mice further demonstrated that FVIOs with the optimal dose of 0.05 μg evoked fear behaviors with an average latency of 2.51 s, which was 2.3-fold faster than that in the SPIO (0.8 μg)-treated group. More importantly, FVIOs-mediated stimulation not only exhibited negligible histopathological alterations and proinflammatory cytokine expression, but also successfully elicited fear behaviors in transgene-free mice. The FVIO-mediated efficient and safe neuromodulation has the potential for future neuroscience exploitation and neurological disease treatment.

Non-invasive brain stimulation (NIBS) is an emerging treatment for mental disorders that is painlessness and easy to administer. However, its effectiveness for treating fear extinction requires further elucidation. We searched eight bibliographical databases and identified randomized controlled trials of NIBS interventions for fear extinction in healthy populations. Outcomes were evaluated based on skin conductance response (SCR) under three experimental conditions: threat condition stimulation (CS+), safe condition stimulation (CS−), and their discrimination (CS+ minus CS−). We applied a random-effects model to determine effect sizes (Hedge’s g) post-intervention and assessed article quality using Physiotherapy evidence database (PEDro) scale. Twenty-one studies meeting systematic review criteria were included in this analysis, incorporating 40 independent effect sizes and data from 11 studies (n = 632) in the meta-analysis. Compared with the control group, the intervention group exhibited significant reductions SCRs: CS+ (g = −0.32, 95% confidence interval (CI) [−0.56, −0.07]) and discrimination (g = −0.35; 95% CI [−0.55, −0.15]). Fear extinction was more effective in the 24-hour test than immediately after NIBS. In conclusion, NIBS enhanced fear extinction, and the time interval between stimulus and testing may serve as a moderating variable.

Introduction :Chronic cholecystitis is a common gastrointestinal pathology all around the world.1 Hyalinizing cholecystitis (HC) was first described by Patel et al characterizes by dense paucicellular hyalinizing sclerosis effacing the gall bladder wall transforming it into a thin uniform band.2 It is recognized as a distinct entity compared to the more heavily calcified “porcelain” gallbladder (PGB).3 Although traditionally associated with higher risk of gallbladder carcinoma (GBC), the association of PGB has recently been brought into question.4,5 On the other hand HC, reported in about 1.6% of cholecystectomy specimens is more consistently associated with GBC.2 Hence identification of radiological as well as histopathological features of HC along with close follow up of patients even after surgery is imperative.

A Case of Breast Filariasis Diagnosed on Fine Needle Aspiration CytologyBirhanu Kassie Reta1 , Biruk Legesse Tadesse2, Eleni Getahun Kebede3, Atsede Birhanu Worku3, Michael Teklehaimanot Abera4Aksum University College of Health Science, Department of Pathology, Aksum, EthiopiaArsi university College of health Science, Department of Pathology, Asella, EthiopiaWoldia University, Woldia, EthiopiaAddis Ababa University, College of Health Sciences, Addis Ababa UniversityAuthors contact Address1. Birhanu Kassie Reta, MD,[email protected] (ORCHID ID: 0009-0001-1897-9072)2.. Biruk Legesse Tadesse, MD, [email protected](ORCHID ID: 0000-0001-6889-5320)3. Eleni Getahun Kebede, MD, [email protected] (ORCHID ID: 0009-0004-8676-1691)4. Atsede Birhanu Worku, MD, [email protected]( ORCHID ID: 0009-0006-0050-9634)5. Michael Teklehaimanot Abera, MD [email protected], [email protected]

not-yet-known not-yet-known not-yet-known unknown The brush straw checkerboard barrier offers a novel approach to sand control and features 60% higher design efficiency and a longer lifespan of 6 years compared to the traditional artificial straw checkerboard barrier. The wind tunnel test and field observation confirmed that the brush straw checkerboard barrier has high sand fixation efficiency. But how do these two sand barriers perform in terms of restoring soil function? How does the effectiveness of restoring soil function change as the service life of the straw checkerboard barrier increases? These questions still need to be clarified further. This study, conducted in Zhongwei, Ningxia, China, examined plots with brush straw checkerboard barrier, artificial straw checkerboard barrier, and bare sand. The results show that the brush straw checkerboard barrier is superior in improving soil moisture, organic matter, total nitrogen and electrical conductivity compared to the artificial straw checkerboard barrier. In addition, the brush straw checkerboard barrier has a positive impact on microbial diversity and community composition. Increasing sand fixation year through the brush straw checkerboard barrier correlates with improved soil properties and microbial indexes, suggesting that it has the potential for widespread application in desertification mitigation.

Abstract: Recent research has shown a strong link between Th17 cells and their cytokine IL-17, and various cardiovascular diseases such as myocarditis, myocardial infarction, and atherosclerosis. Moreover, Th17 cell signalling is likely to be a key factor in cardiovascular disease. Here, we summarize recent advances in the source, function, regulation, and the effects of Th17 signaling in cardiovascular disease. Research on Th17 will suggest more specific strategies to manipulate these functions. Thus, effective treatment of cardiovascular disease and future clinical treatment will be possible.

Ecosystems may exist in alternative stable states and thereby extremely differ in ecosystem structure and functions, including gross primary productivity (GPP), which is crucial for assessing an ecosystem’s ability to capture atmospheric carbon dioxide, especially under the context of climate change. This study applied alternative stable states theory to evaluate GPP in global dryland forests, and analyzed multi-year average GPP data alongside environmental factors such as the Aridity Index and mean annual precipitation. Here, we found the existence of alternative stable states of GPP along the aridity gradient. Mean GPP were 893.12 gC/m²/year and 1539.86 gC/m²/year under lower and higher branches of alternative stable states, respectively, compared to the current mean value of 1203.02 gC/m²/year. Notably, we observed striking regional disparities in GPP, with Africa and Oceania predominantly in the higher alternative stable state, while North America and Asia were in the lower alternative stable state. However, GPP along mean annual precipitation did not exhibit alternative stable states, but a significant variation during the medium range of mean annual precipitation (241-402 mm year-1). The relationships between GPP data and environmental factors were consistent across different forest types. This study sheds light on dryland forest productivity and indicates adaptive management strategies that should be used to bolster ecosystem function in the context of climate change.

not-yet-known not-yet-known not-yet-known unknown Pulmonary Mucormycosis in a Patient with Decompensated Cirrhosis of the Liver Successfully Treated with Oral Posaconazole- A Case Report

Four significant influenza outbreaks have occurred over the past 100 years, and the 1918 flu pandemic is the most severe. Since influenza viruses undergo antigenic evolution, they are the pathogens most likely to trigger a new pandemic shortly. Intranasal vaccination offers a promising strategy for preventing diseases triggered by respiratory viruses by eliciting an immunoglobulin A (IgA) response, limiting virus replication and transmission from the respiratory tract more efficiently than intramuscular vaccines. Combining intranasal administration and mRNA-lipid nanoparticles can be an ideal strategy for limiting the extent of the next flu pandemic. This study explored the immunogenicity of intranasally delivered mRNA encapsulated in mannose-histidine-conjugated chitosan lipid nanoparticles (MHCS-LNPs) as a vaccine against influenza A (H1N1) in BALB/c mice. Intranasal administration of mRNA-MHCS-LNPs resulted in the generation of influenza A (H1N1) hemagglutinin-specific neutralizing antibodies in vaccinated animals. The ELISA results indicated a notable increase in the quantity of IgG and IgA antibodies in serum and the Bronchoalveolar Lavage Fluid (BALF), respectively, and exhibited influenza A-specific IFN-γ secretion in vaccinated mice, as well as a noticeable alteration in IL-5 production. Overall, this study demonstrated an effective immunogenic response against respiratory viral infections through intranasal delivery of an mRNA-MHCS-LNP vaccine.