Aims: Premature ejaculation (PE) is a common sexual dysfunction that significantly affects the quality of life of the patient and their partner. We aimed to compare efficacy and safety of the combination therapy with biofeedback-guided pelvic floor exercise therapy (BFT) and dapoxetine 30 mg. Results: Patients were divided into three groups as BFT, dapoxetine 30 mg and combination with BFT and dapoxetine 30 mg. The patients were compared with the intravaginal ejaculatory latency time (IELT) pre-treatment and post-treatment 1st and 3rd months. The mean IELTs of the patients in Group 1 were 40 sec in pre-treatment, 115 sec at the end of the 4th week and 140 sec at the end of the 12th week. The IELT values of the patients in Group 2 were 40 sec in pre-treatment, 145 sec in the 4th week and 170 sec in the 12th week . The IELT values were calculated in Group 3 as 42.5 sec in pre-treatment, 185 sec in the 4th week and 205 sec in the 12th week When the IELT was statistically compared between the groups at 1st and 3rd months, the duration in combination group was found to increase significantly (p < 0.001). Discussion: Pelvic floor muscles play an important role in sexual function. Rehabilitation of pelvic floor muscles provides two-stage efficiency with electrostimulation and physiokinesitherapy; it aims to improve the contractile forces of the perineal muscles and increase the urethral sphicter closure force. Besides, the rehabilitation of pelvic floor muscles allows patients to control the contractions of the right muscle group accompanied by biofeedback Conclusion: Combination therapy with BFT and dapoxetine 30 mg in lifelong PE treatment is a good alternative with low side effect profile and acceptable continuous efficiency