Land use land cover change is the main factor which contributed to biodiversity loss, and has affected negatively human wellbeing. Understanding this phenomenon is important in Riverine area of Pendjari Reserve which has been affected by anthropic disturbance for century years, and is, nowadays, one of the most significantly biodiversity hotspots in the West Africa. This study aims to (i) assess the trends of land use land cover change from 1998 to 2020; (ii) predict the future of land use land cover change for 2035 and 2050. Landsat images were used to determine LULC dynamics for the years 1998, 2007, 2013 and 2020 using Random Forest classification in ArcGIS software while the predicted LULC of 2035 and 2050 were simulated using Terset 18.21. The results indicated significant changes in LULC patterns. The wooded savannah decreased by 4.7 %, 8 % and 11.5 % respectively during 1998-2007, 2007-2013 and 2013-2020. While shrub savannah increased by 10.5% and 3.88 % respectively 1998-2007 and 2007-2013 before declined by 1.17%. However, the cropland from 1998-2007 decreased by 6.66 %, before increased by 4.33% and 11.1% respectively from 2007-2013 and 2013-2020. Fallow land increased by 0.77 %, 0.83 % respectively 1998-2007 and 2013-2020, before decreasing by 0.7 % in 2007-2013. Settlement area increased from 1998-2020. The prediction results confirmed small decreased of wooded savannah and increased shrub savannah, cropland and fallow. Moreover, results of 2035 predicted settlement decreased in future and suggest African partnership will continuous for better land management of this study area. For year 2050, the wooded savannah will increase by 17506.7 Ha with 583.557 Ha/year -1 rate of change.