Objective This study aims to investigate the factors affecting development of acute kidney injury (AKI) due to severe hypothyroidism. Methods This single-centre, retrospective observational study involved patients with primary hypothyroidism and thyroid stimulating hormone (TSH) levels of more than 50 mIU/L at their review in the endocrinology outpatient clinic, between January 2015 and April 2021. Patients whose medical history and laboratory data were complete were included in the study. Demographic and laboratory data of patients with AKI (case group) and without (control group) were compared. Factors affecting the development of AKI were examined by logistic regression analysis. Results A total of 100 patients, 20 (11 male (M), 9 female (F)) in the AKI (case) group and 80 (23 M, 57 F) patients in control group, were included in our study. The median age of the case group (56 years, interquartile range (IQR) 44.3–68.5) was significantly higher than the control group (49 years, IQR 32.3–60; p = 0.027), and the ratio of males to females was significantly higher in the case group (p = 0.001). Multivariate logistic regression analyses showed that hypothyroidism diagnosed after the age of 60 years (odds ratio (OR) 59.674, 95% confidence intervals (CI) 5.955–598.031; p = 0.001), free triiodothyronine (FT3) < 1.3 pg/mL (OR 17.151, 95% CI 2.491–118.089; p = 0.004) and creatine kinase (CK) > 1000 U/L (OR 1.522, 95% CI 1.602–82.848; p = 0.015) were predictors for the development of AKI due to severe hypothyroidism. Conclusion We recommend close follow-up and monitoring of patients with AKI caused by severe hypothyroidism if aged > 60 years, CK > 1000 U/L or FT3 < 1.3 pg/mL.

Purpose: We aimed to investigate the relationship between the staining rates of thrombospondin-1, VEGF and PDGFR-in tissue preparations in patients diagnosed with DLBCL as a result of lymphadenopathy biopsy and their clinical features at the time of diagnosis, response to treatment and prognosis. Materials and Methods: For this purpose, a total of 44 patients with a diagnosis of DLBCL, 24 male and 20 female, and 13 patients diagnosed with control reactive lymphadenopathy, 6 male and 7 female were enrolled. After the pathology preparations of the patient and control groups were stained immunohistochemically with VEGF, PDGFR-β, thrombospondin-1 stains, the clinical characteristics of the patients and the relationship between survival analysis and staining rates were analyzed statistically. Results: When the patients were compared with the control group in terms of VEGF, PDGFR-β, thrombospondin-1 staining rates, we found that staining with PDGFR-β was lower in patients (p = 0.009). Although it was not statistically significant for PDGFR-β, it was observed that 5-year OS and PFS values were low in patients with high levels of expression, on the contrary, 5-year OS was low in patients with high thrombospondin staining rate. A negative correlation was seen between thrombospondin-1 and PDGFR-β (p=0.003, r=-0.440). Conclusion: As a result, although no relationship was found between VEGF and survival in our study, it was observed that PDGFR-β and thrombospondin-1 were effective in prognosis. A negative correlation was seen between thrombospondin-1 and PDGFR-β.

Background and Aim:The novel coronavirus (SARS-CoV-2) that causes novel coronavirus pneumonia (COVID-19) is the third fatal coronavirus. The prognosis of disease varies depending on patient’s specialties. The aim of this study was to evaluate the correlation of CBC parameters and ferritin levels at the time of diagnosis with the prognosis of patients hospitalized due to COVID 19. Materials and Methods: In this retrospective study, 1320 patients hospitalized at the Aksaray University Training and Research Hospital between July 2020 and December 2020 were evaluated. Results: All of the patients were hospitalized because of symptoms associated with COVID 19. There were 688 males and 632 females with a median age of 70 (19-98) at the time of hospitalization with COVID 19 symptoms. The median follow-up time was 7 (range, 1-57) days in hospital for all patients. Median age was significantly higher in patients who do not respond to treatment and have mortality (p<0.001). Most of the patients with mortality were males (p=0.001). There was a statistically significant difference in the parameters other than monocyte and basophil among the hemogram parameters checked at the time of presentation. Neutrophil / lymphocyte ratio was significantly higher in patients with mortality (p<0.001). Conclusion: In conclusion, this study indicates that by using the most simple and routine hematological tests at the time of COVID-19 diagnosis, it may be possible to predict a patient’s prognosis. This will help patients receive early clinical care, reducing patient mortality and aiding in the control and prevention of the outbreak.